DOI Page / Citation link:
https://doi.org/10.11588/diglit.48120#0032
14
Molecular and Cell Biology of Autoantibodies and Autoimmunity
elevated. In addition, emphasis will be placed on the discussion of autoantibodies
to certain cytoskeletal proteins that seem to be causally related to the origin and
progression of a disease such as certain pemphigus antigens [11] and of the
enigma of apparently “constitutive” autoantibodies to certain proteins in normal
mammals, using xanthine oxidase antibodies as a particularly well studied exam-
ple [12]. The experimental observations of autoantibodies to cytoskeletal proteins
in both diseased and normal persons are also discussed in relation to the different
hypotheses proposed for their possible biological and pathogenic functions (e.g.,
13, 14).
References
1. Franke, W. W. (1987): Nuclear lamins and cytoplasmic intermediate filament pro-
teins: a growing multigene family. Cell 48, 3-4
2. Kurki, P., Virtanen, I., Lehto, V.-R, Alfthan, O., Salaspuro, M. (1984): An-
tibodies to cytokeratin filaments in patients with alcoholic liver disease. Alcohol. Clin.
Exp. Res. 8, 212-215
3. Kurki, R, Virtanen, I. (1985): The detection of smooth muscle antibodies reacting
with intermediate filaments of desmin type. Journal of Immunological Methods 76,
329-335
4. Galbraith, G. M.P, Emerson, D., Fudenberg, H.H., Gibbs, C.J., Gajdusek,
D. C. (1986): Antibodies to neurofilament protein in retinitis pigmentosa. J. Clin. In-
vest. 78, 865-869
5. Iwatsuki, K., Viac, J., Reano, A., Morera, A., Staquet, M.-J., Thivolet, J.,
Monier, J.-C. (1986): Comparative studies on naturally occurring antikeratin an-
tibodies in human sera. J. Invest. Dermatol. 87, 179-184
6. Franke, W. W., Cowin, P, Schmelz, M., Kapprell, H.-P. (1987): The desmosomal
plaque and the cytoskeleton. In: Junctional Complexes of Epithelial Cells. Ciba Foun-
dation Symposium 125. Wiley & Sons, Chichester, pp. 26-44
7. Koulu, L., Kusumi, A., Steinberg, M.S., Klaus-Kovtun, V., Stanley, J.R. (1984)
Human autoantibodies against a desmosomal core protein in pemphigus foliaceus. J.
Exp. Med. 160, 1509-1518
8. Matis, W.L., Anhalt, G. J., Diaz, L.A., Rivitti, E.A., Martins, C.R., Berger,
R. S. (1987): Calcium enhances the sensitivity of immunofluorescence for pemphigus
antibodies. J. Invest. Dermatol. 89, 302-304
9. Stanley, J.R., Tanaka, T., Mueller, S., Klaus-Kovtun, V., Roop, D. (1988):
Isolation of complementary DNA for bullous pemphigoid antigen by use of patients1
autoantibodies. J. Clin. Invest. 82, 1864-1870
10. Jarasch, E.-D., Grund, C., Bruder, G., Heid, H.W., Keenan, T.W., Franke,
W. W. (1981): Localization of xanthine oxidase in mammary gland epithelium and
capillary endothelium. Cell 25, 67-82
11. Anhalt, G. J., Labib, R. S., Voorhees, J. J., Beals, T. E, Diaz, L.A. (1982): Induc-
tion of pemphigus in neonatal mice by passive transfer of IgG from patients with the
disease. N. Engl. J. Med. 106, 1189—1196
Molecular and Cell Biology of Autoantibodies and Autoimmunity
elevated. In addition, emphasis will be placed on the discussion of autoantibodies
to certain cytoskeletal proteins that seem to be causally related to the origin and
progression of a disease such as certain pemphigus antigens [11] and of the
enigma of apparently “constitutive” autoantibodies to certain proteins in normal
mammals, using xanthine oxidase antibodies as a particularly well studied exam-
ple [12]. The experimental observations of autoantibodies to cytoskeletal proteins
in both diseased and normal persons are also discussed in relation to the different
hypotheses proposed for their possible biological and pathogenic functions (e.g.,
13, 14).
References
1. Franke, W. W. (1987): Nuclear lamins and cytoplasmic intermediate filament pro-
teins: a growing multigene family. Cell 48, 3-4
2. Kurki, P., Virtanen, I., Lehto, V.-R, Alfthan, O., Salaspuro, M. (1984): An-
tibodies to cytokeratin filaments in patients with alcoholic liver disease. Alcohol. Clin.
Exp. Res. 8, 212-215
3. Kurki, R, Virtanen, I. (1985): The detection of smooth muscle antibodies reacting
with intermediate filaments of desmin type. Journal of Immunological Methods 76,
329-335
4. Galbraith, G. M.P, Emerson, D., Fudenberg, H.H., Gibbs, C.J., Gajdusek,
D. C. (1986): Antibodies to neurofilament protein in retinitis pigmentosa. J. Clin. In-
vest. 78, 865-869
5. Iwatsuki, K., Viac, J., Reano, A., Morera, A., Staquet, M.-J., Thivolet, J.,
Monier, J.-C. (1986): Comparative studies on naturally occurring antikeratin an-
tibodies in human sera. J. Invest. Dermatol. 87, 179-184
6. Franke, W. W., Cowin, P, Schmelz, M., Kapprell, H.-P. (1987): The desmosomal
plaque and the cytoskeleton. In: Junctional Complexes of Epithelial Cells. Ciba Foun-
dation Symposium 125. Wiley & Sons, Chichester, pp. 26-44
7. Koulu, L., Kusumi, A., Steinberg, M.S., Klaus-Kovtun, V., Stanley, J.R. (1984)
Human autoantibodies against a desmosomal core protein in pemphigus foliaceus. J.
Exp. Med. 160, 1509-1518
8. Matis, W.L., Anhalt, G. J., Diaz, L.A., Rivitti, E.A., Martins, C.R., Berger,
R. S. (1987): Calcium enhances the sensitivity of immunofluorescence for pemphigus
antibodies. J. Invest. Dermatol. 89, 302-304
9. Stanley, J.R., Tanaka, T., Mueller, S., Klaus-Kovtun, V., Roop, D. (1988):
Isolation of complementary DNA for bullous pemphigoid antigen by use of patients1
autoantibodies. J. Clin. Invest. 82, 1864-1870
10. Jarasch, E.-D., Grund, C., Bruder, G., Heid, H.W., Keenan, T.W., Franke,
W. W. (1981): Localization of xanthine oxidase in mammary gland epithelium and
capillary endothelium. Cell 25, 67-82
11. Anhalt, G. J., Labib, R. S., Voorhees, J. J., Beals, T. E, Diaz, L.A. (1982): Induc-
tion of pemphigus in neonatal mice by passive transfer of IgG from patients with the
disease. N. Engl. J. Med. 106, 1189—1196