DOI Seite / Zitierlink:
https://doi.org/10.11588/diglit.48120#0075
Abstracts
57
The anti-Wa Ab was observed in 3% (4/130) of patients with PSS, but not in
600 patients with systemic lupus erythematosus. This antibody was not associated
with other marker antibodies seen in PSS such as anti-ScI 70 and anti-centromere
antibodies. None of the four PSS patients had myositis except one patient who
complained of mild myalgia. At present those patients do not show clinical
overlap feature of PSS and polymyositis/dermatomyositis. Summary of clinical
manifestation is as shown on page 56.
Characteristics and Interrelation of Autoantibodies in Scleroderma Sera
Y. Moroi
Dept, of Internal Medicine and Physical Therapy, University of Tokyo, Tokyo, Japan
Several kinds of autoantibodies against cellular components have been so far
characterized and proved to be specific in various degree for the patient with
scleroderma. These include antibodies against topoisomerase I (Topol), cen-
tromere, nRNP, nucleolus, mitochondria, centriole and mitotic spindle.
We analyzed immunoglobulin class and titer of anti-Topol by ELISA using
chemically purified Topol as antigen. Anti-centromere antibody was also analyz-
ed by indirect immunofluorescence (IF) method.
All the scleroderma sera which contained anti-Scl 70 antibody by double-im-
munodifusion (DID) showed positive IgG anti-Topol by ELISA. About 60% of
these sera also contained IgA class antibody, but no IgM antibody was detected.
Same tendency was observed in case of anti-centromere antibody, namely IgG an-
ti-centromere in all the sera, IgA antibody in about 60% and IgM antibody in
less than 30% of the sera which was positive anti-centromere by FITC-anti
globulin. Interrelation of these antibodies including anti-centromere, centriole
and mitotic spindle will be discussed.
57
The anti-Wa Ab was observed in 3% (4/130) of patients with PSS, but not in
600 patients with systemic lupus erythematosus. This antibody was not associated
with other marker antibodies seen in PSS such as anti-ScI 70 and anti-centromere
antibodies. None of the four PSS patients had myositis except one patient who
complained of mild myalgia. At present those patients do not show clinical
overlap feature of PSS and polymyositis/dermatomyositis. Summary of clinical
manifestation is as shown on page 56.
Characteristics and Interrelation of Autoantibodies in Scleroderma Sera
Y. Moroi
Dept, of Internal Medicine and Physical Therapy, University of Tokyo, Tokyo, Japan
Several kinds of autoantibodies against cellular components have been so far
characterized and proved to be specific in various degree for the patient with
scleroderma. These include antibodies against topoisomerase I (Topol), cen-
tromere, nRNP, nucleolus, mitochondria, centriole and mitotic spindle.
We analyzed immunoglobulin class and titer of anti-Topol by ELISA using
chemically purified Topol as antigen. Anti-centromere antibody was also analyz-
ed by indirect immunofluorescence (IF) method.
All the scleroderma sera which contained anti-Scl 70 antibody by double-im-
munodifusion (DID) showed positive IgG anti-Topol by ELISA. About 60% of
these sera also contained IgA class antibody, but no IgM antibody was detected.
Same tendency was observed in case of anti-centromere antibody, namely IgG an-
ti-centromere in all the sera, IgA antibody in about 60% and IgM antibody in
less than 30% of the sera which was positive anti-centromere by FITC-anti
globulin. Interrelation of these antibodies including anti-centromere, centriole
and mitotic spindle will be discussed.