300 | FÖRDERUNG DES WISSENSCHAFTLICHEN NACHWUCHSES

Resume
Mit Hilfe von physikalischen, biologischen und mathematischen Methoden haben
wir versucht, erste Einblicke in die basalen Regulationsmechanismen zu erlangen,
die der 3D-Formbildung aus 2D-Morphogengradienten in biologischen Geweben
zugrunde liegen. Wir schließen mit der Feststellung „Our real teacher bas been and still
is the embryo, who is, incidentally, the only teacher who is always right.“ Viktor Hamburger
(Holtfreter,} 1968) [9],
Referenzen:
[1] Alexander Koerner, Christina Deichmann, Fernanda F. Rossetti, Almut Koehler,
Oleg V. Konovalov, Doris Wedlich and Motomu Tanaka, Cell Differentiation of
Pluripotent Tissue Sheets Immobilized on Supported Membranes Displaying
Cadherin—11, PLOS one,Volume 8, Issue 2 (2013)
[2] Alexander Koerner, Wasim Abuillan, Christina Deichmann, Fernanda F. Rossetti,
Almut Koehler, OlegV Konovalov, Doris Wedlich and Motomu Tanaka, Quanti-
tative Determination of Lateral Concentration and Depth Profile of Histidine-
Tagged Recombinant Proteins Probed by Grazing Incidence X.ray Fluorescence,
J. Phys. Chem. B 117, 5002-5008 (2013)
[3] S. Kumar, M. Zigman, T. R. Patel, B.Trageser, J. C. Gross, K. Rahm, M. Boutros,
D. Gradl, H. Steinbeisser,}. Stetefeld, S. Özbek: Molecular Dissection ofWnt3a-
Frizzled8 Interaction Reveals Essential and Modulatory Determinants ofWnt
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[5] M. Zigman, Laumann-Lipp N., T. Titus, J. Postlethwait, C.B. Moens: Hoxblb
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puting of deformation dynamics of inhomogeneous biological surfaces, SIAM
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[7] Mercker M, Hartmann D, Marciniak-Czochra A: A mechanochemical model for
embryonic pattern formation: Coupling tissue mechanics and morphogen
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[8] Soriano J, Rüdiger S, Pullarkat P, Ott O Mechanogenetic Coupling of Hydra
Symmetry Break and Driven Turing Instability Model. Biophysical Journal 96:
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[9] Holtfreter,}. Address in honor ofViktor Hamburger. In Locke, M. (ed.) The
Emergence of Order in Developing Systems.The Twenty-Seventh Symposium of
the Society for Developmental Biology. Academic Press, NY. IX—XX. (1968).