DOI chapter:
A. Das akademische Jahr 2015
DOI chapter:I. Jahresfeier am 30. Mai 2015
DOI chapter:Festvortrag von Stefan Hell: „Grenzenlos scharf: Lichtmikroskopie im 21. Jahrhundert“
DOI Page / Citation link: https://doi.org/10.11588/diglit.55653#0032
I. Jahresfeier am 30. Mai 2015
vidually and stochastically in space. While 4Pi microscopy did not overcome thc
diffraction barrier per se, both STED-like and stochastic variants of subdiffraction
resolution fluorescence microscopy have now been implemented with cohcrently
used juxtaposed objective lenses in order to provide the largest axial and hcnce 3D-
resolution possible.
Today’s ‘superresolution’ fluorescence microscopy or ‘nanoscopy’ funda-
mentally differs from the diffraction-limited one in that the Separation of adjacent
structural details is not accomplished just by focusing the light in use, but through
the transient occupation of two different molecular States. In my view, this prin-
ciple is so fundamental that it ofifers many opportunities to develop a whole ränge
of powerful ‘superresolution’ variants. I am delighted to see how this field is un-
folding and how it is advancing the life Sciences as well as other areas. Meanwhile
all major microscope manufacturers offer ‘superresolution’ microscopes as their
flagship products. Yet, there is still much to be done and I still have a lot of passion
contributing to the advancement of this field. I was also fortunate over the years to
be accompanied by further outstanding studcnts and postdoctoral scientists who
have joined this quest, making important contributions: Martin Schrader, Alexan-
der Egner, Andreas Schönle, Jörg Bewersdorf, Volker Westphal, Lars Kastrup, Jan
Keller, Gerald Donnert, Johann Engelhardt, Vladimir Belov, and Christian Egge-
ling, to name just a few.
Today, now co-responsible for the new generation of scientists, I often won-
der whether the way in which Science is organiscd, sufficiently encourages young
researchers to pursue unusual research topics. So far I have kept myself well out
of administrative duties and Science policy-making - to the delight of my group,
but not always of my colleagues. But one thing remains close to my heart: I have
recently launched an initiative to explore new ways of helping young researchers
to embark on risky projects at an early stage of their career. And since many of my
colleagues in the Max Planck Society also find this idea very interesting, I am opti-
mistic that this endeavour will work out as well.
32
vidually and stochastically in space. While 4Pi microscopy did not overcome thc
diffraction barrier per se, both STED-like and stochastic variants of subdiffraction
resolution fluorescence microscopy have now been implemented with cohcrently
used juxtaposed objective lenses in order to provide the largest axial and hcnce 3D-
resolution possible.
Today’s ‘superresolution’ fluorescence microscopy or ‘nanoscopy’ funda-
mentally differs from the diffraction-limited one in that the Separation of adjacent
structural details is not accomplished just by focusing the light in use, but through
the transient occupation of two different molecular States. In my view, this prin-
ciple is so fundamental that it ofifers many opportunities to develop a whole ränge
of powerful ‘superresolution’ variants. I am delighted to see how this field is un-
folding and how it is advancing the life Sciences as well as other areas. Meanwhile
all major microscope manufacturers offer ‘superresolution’ microscopes as their
flagship products. Yet, there is still much to be done and I still have a lot of passion
contributing to the advancement of this field. I was also fortunate over the years to
be accompanied by further outstanding studcnts and postdoctoral scientists who
have joined this quest, making important contributions: Martin Schrader, Alexan-
der Egner, Andreas Schönle, Jörg Bewersdorf, Volker Westphal, Lars Kastrup, Jan
Keller, Gerald Donnert, Johann Engelhardt, Vladimir Belov, and Christian Egge-
ling, to name just a few.
Today, now co-responsible for the new generation of scientists, I often won-
der whether the way in which Science is organiscd, sufficiently encourages young
researchers to pursue unusual research topics. So far I have kept myself well out
of administrative duties and Science policy-making - to the delight of my group,
but not always of my colleagues. But one thing remains close to my heart: I have
recently launched an initiative to explore new ways of helping young researchers
to embark on risky projects at an early stage of their career. And since many of my
colleagues in the Max Planck Society also find this idea very interesting, I am opti-
mistic that this endeavour will work out as well.
32